Gasotransmitters and Protein Post-Translational Modifications
نویسندگان
چکیده
منابع مشابه
Post-translational modifications of protein biopharmaceuticals.
The majority of therapeutic proteins display one or more post-translational modifications (PTMs). These modifications normally influence the biochemical and therapeutic properties of such proteins. Choosing an expression system capable of generating an appropriate product PTM profile remains one of the most crucial decisions a drug developer must make. This review considers the PTMs most often ...
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The unique and remarkable physicochemical properties of protein surface topologies give rise to highly specific biomolecular interactions, which form the framework through which living systems are able to carry out their vast array of functions. Technological limitations undermine efforts to probe protein structures and interactions within unperturbed living systems on a large scale. Rapid chem...
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Gene expression can be regulated in many ways at the level of transcription or translation. The quickest way is to modify the gene product or protein. Post-translational modifications (PTMs) of proteins can alter their activity, interaction partners, complex affiliation, subcellular localization, or stability in response to changes in the cellular environment. There is a well-established and di...
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Protein post-translational modifications (PTMs) allow the cell to regulate protein activity and play a crucial role in the response to changes in external conditions or internal states. Advances in mass spectrometry now enable proteome wide characterization of PTMs and have revealed a broad functional role for a range of different types of modifications. Here we review advances in the study of ...
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Microtubules are the largest filamentous components of the eukaryotic cytoskeleton. In spite of their extraordinary level of structural conservation, microtubules fulfill a vast range of different functions in cells. How this functional diversity is achieved remains an open question; however, recent advances point towards post-translational modifications (PTMs) of tubulin as a potent mechanism ...
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ژورنال
عنوان ژورنال: MOJ Proteomics & Bioinformatics
سال: 2017
ISSN: 2374-6920
DOI: 10.15406/mojpb.2017.05.00165